Advanced Glycation End Products (AGE) for Diabetes

Advanced Glycation End Products (AGE) for Diabetes Diabetes mellitus is a syndrome which defined as a group of metabolic diseases characterized by hyperglycemia, that result from insufficient production of insulin, or body cells poorly respond to the insulin that is produced, or both. Insulin is a hormone produced in the pancreas and secreted in the blood to maintain blood glucose in the body through enables body cells to absorb glucose, to turn into energy. If the body cells enable to absorb the glucose, the glucose will accumulates in the blood (hyperglycemia), leading to many and different potential medical complications (Harmel & Mathur, 2004). Diabetes have several categories but the majority of cases fall into two categories which are type 1 diabetes mellitus and type 2 diabetes mellitus. These two types are powerful and highly independent risk factors causing coronary artery disease, stroke, peripheral arterial disease and organ damage and dysfunction including eyes and nerves (Harmel & Mathur, 2004). Type 1 Diabetes Mellitus : Type 1 diabetes mellitus resulting from pancreas failure to produce insulin hormone. Person at risk of developing type 1 can be identified by doing serologic test markers that showing evidence of autoimmune destruction of beta cells (islet cells) of the pancreas which is responsible for insulin production. Type 1 diabetes is manifested in childhood and early adulthood, but can patient present at any age (Goroll & Mulley, 2009). Type 2 diabetes mellitus: Patients with type 2 diabetes mellitus are prone with wide range of series complications. Type 2 is characterized by high blood glucose due to insulin resistance and relative insulin deficiency. There are 20.8 million people in United State with type 2 diabetes mellitus. Type 2 diabetes traditionally is seen in elderly people. However it is diagnosed in obese children. Many studies shows that type 2 diabetes mellitus are associated with high calorie diet, physical inactivity and life style (Feinglos & Bethel, 2008). Other Types of Diabetes: There are other types of diabetes but they are less common but patients who are underlying defect or disease process can be identified in a relatively specific manner. These types are Genetic defects of beta-cell function, Diseases of the exocrine pancreas e.g Fibrocalculous pancreatopathy, Endocrinopathies and cystic fibrosis and Uncommon forms of immune-mediated diabetes. Diabetes mellitus complications: Diabetic complications can be grouped into macrovascular and microvascular disease. Macrovascular diseases are result from atherosclerosis which develops in earlier age in patient with diabetes. There are several factors contribute to atherosclerosis such as lipidemia, hypertension, increased platelets adhesion and aggregation, elevated factor V, factor VII and fibrinogen concentration. Macrovascular diseases are seen in both type one and two of diabetes mellitus and they include coronary heart disease, Ischemic stroke and peripheral vascular disease (which can lead to u lcers, gangrene and amputation) (Winter & Signorino, 2002). Whereas, Microvascular complications is seen in type one diabetes mellitus. Hyperglycemia damages the basement membrane of capillaries in the retina and glomerulars which leads to retinopathy and neuropathy. Microvascular diseases include neuropathy (nerve damage), nephropathy (kidney disease) and vision disorders (eg retinopathy, glaucoma, cataract and corneal disease). Furthermore there are other complications of diabetes include infections, metabolic difficulties, dental disease, autonomic neuropathy and pregnancy problems (Winter & Signorino, 2002).

Employee Training and Development at Abbott Case Study

Employee Training and Development at Abbott - Case Study Example Abbott has received numerous local, national and international distinctions for its commitment to workplace excellence. Abbott has been named one of the best places to work in the world. It has received many awards for its unique performance and its concern and care for its workforce safety, growth and development and success and excellence. The present study covers some of the important areas in employee training and development that have made it a distinct company. Strategic training is directly linked with the business strategy of a company. It begins with identifying the business strategy. Then strategic training and development initiatives that support the strategy are selected and these are translated into concrete training and development activities. The final step involves identifying measures or metrics. These metrics are used to determine if training helped contribute to goals related to business strategy. (Noe. 2008) As Raymond Noe rightly points out, the company's mission, vision, values and goals help to determine the strategy. The mission is the company's reason for existing. The vision is the picture of what company does in the future and what it wants to achieve. Values are what the company stands for. SWOT analysis really helps a company to identify its strengths and weakness and an analysis of its operating environment to identify opportunities and threats. It studies closely the internal and external factors that affect its performance. This analysis goes a long way in formulating the business strategy. The company has to consider its competition. It will decide how the company will compete with others in the market. There are three main points to consider when planning the strategy for competing. They are: 1) where to compete 2) How to compete 3) With what will it compete Abbott has a clear business strategy with its clear mission and vision statements and thorough SWOT analysis.- Once the business strategy is clear then strategic training and development initiatives that support the Strategy are identified. Strategic training and development initiatives are learning-related actions that a company should take to help it achieve its business strategy. (Noe, 2008) These initiatives are based on the business environment, an understanding of the company's goals and resources and insight regarding potential training and development options. These provide the company a road map to guide specific training and development activities. One of the initiatives in strategic training is to diversifying the learning portfolio by using new technology, facilitating informal learning, and providing more personalized learning opportunities. Expanding who are trained is another major initiative in strategic training. It includes customers, suppliers and employees. It also aims at providing training for non-managerial employees. Accelerating the Pace of Employee learning is another major strategic training initiative. It helps in quickly identifying needs and providing a high-quality learning solution, reducing the time to develop training programs and

Point of Service Plans Article Example | Topics and Well Written Essays - 1000 words

Point of Service Plans - Article Example The health care sector has changed its insurance plans which used to be high but were being paid in large amounts by the employers to a â€Å"more cheaper, manageable and consolidated† plan where the patient (employee of the family member of the employee) receives medical care from one point and the physician acts as the point of service of the patient (Point of Service health plan). The new plan as explained in detail by the article reduces the health care costs but at the same time increases other costs like family deductibles, premiums and even the out-of-pocket expenses. All these expenses are almost fully paid by the employee and not the employer and hence increasing event he burden of health care further than it previously was before this new merger of Preferred Provider Organization plan (PPO) and Health Maintenance Organization plan (HMO) that brought about the birth of Point of Service plan (POS) was formulated and implemented. The latest statistics collected by the Bureau of Labor Statistics (BLS) in the United States of America show that the employer no longer fully caters for the health care plans of their full time employees. The statistics indicate that in 1998, over 86% of the employees participated in a medical insurance plan which catered for all their health problems. However, data collected in 2011 shows that only an average of 82% of the employees are involved in a medical plan. The plan the government employees were being offered and are still being offered is the Point of Service Plan. The decline in the health care plan has been pin-pointed to certain services like dental care, prescription drug coverage for outpatients and even in visual care. This is attributed to the fact that these services are costly and hence the employees cannot afford to pay for them. These services are also usually not provided in local health care centers and hence requires the